Endocrine Abstracts

Introduction: Iodine is important for thyroid hormone synthesis, and iodine deficiency in pregnancy may impair foetal neurological development. Perchlorate, found in some foods and everyday chemicals (e.g. fertilisers) and thiocyanate, which is found in cigarette smoke, decrease the transport of iodine from the circulation to the thyroid cells by inhibiting the sodium-iodide symporter. Environmental exposure to these substances during pregnancy may result in reduced thyroid ho...

Introduction: Iodine is important for thyroid hormone synthesis, and iodine deficiency in pregnancy may impair foetal neurological development. Perchlorate, found in some foods and everyday chemicals (e.g. fertilisers) and thiocyanate, which is found in cigarette smoke, decrease the transport of iodine from the circulation to the thyroid cells by inhibiting the sodium-iodide symporter. Environmental exposure to these substances during pregnancy may result in reduced thyroid ho...

Background: Iodine deficiency and excess are well-recognized risk factors for thyroid dysfunction. This systematic reveiw and meta-analysis was designed, for the first time, to explore whether maternal iodine status or supplementation is associated with postpartum thyroid function.Methods: Electronic databases, including the MEDLINE/PubMed, Web of Science, Embase, and Scopus were searched between January 1923 and December 2021 to identify relevant studie...

Importance: Thyroid hormone is essential for cognitive development. The Thr92Ala substitution in deiodonase-2 appears to reduce intracellular availability of active thyroid hormone. Individuals with low-normal serum thyroid hormone levels and this substitution might have insufficient intracellular thyroid hormone for optimal cognitive development.Objective: To explore whether individuals with low thyroid hormone bioavailability – free thyroxine in t...